![]() Long-term oral/systemic corticosteroid use was, in general, less frequent than short-term use. Overall, oral/systemic corticosteroids were commonly used for asthma management and were more frequently used in patients with severe asthma than in those with milder disease. ![]() The included studies were conducted in Europe, North America, and Asia. ![]() We identified and reviewed 387 full-text articles, and our review included data from 139 studies. Observational studies, prescription database analyses, economic analyses, and surveys on oral/systemic corticosteroid use in children (>5 yr old), adolescents (12–17 yr old), and adults with asthma were included. We searched MEDLINE and Embase databases to identify English-language articles published in 2010–2017, using search terms for asthma with keywords for oral corticosteroids and systemic corticosteroids. ![]() We conducted a systematic literature review to investigate the real-world extent and burden of systemic corticosteroid use in asthma. Systemic corticosteroid use to manage uncontrolled asthma and its associated healthcare burden may account for important health-related adverse effects.
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